Perfume induces a dose-dependent non-IgE-mediated release of histamine from human peripheral blood basophils. Increased basophil reactivity to perfume was found in patients with respiratory symptoms related to perfume.
Elberling, J., Skov, P., Mosbech, H., Holst, H., Dirksen, A. and Johansen, J. (2007). Increased release of histamine in patients with respiratory symptoms related to perfume. Clinical & Experimental Allergy, 37(11), pp.1676-1680.
Full article: https://www.ncbi.nlm.nih.gov/pubmed/17877753